MANZAMINE A
- Product Name
- MANZAMINE A
- CAS No.
- 104196-68-1
- Chemical Name
- MANZAMINE A
- Synonyms
- MANZAMINE A;Keramamine A;1,13-Etheno-4,21a-methano-1H-azocino[1',2':1,5]pyrrolo[3,2-e]azacyclopentadecin-13(13aH)-ol, 2,3,5,6,7,8,11,12,15,16,17,18,20a,21-tetradecahydro-24-(9H-pyrido[3,4-b]indol-1-yl)-, (1R,4S,9Z,13S,13aR,20aR,21aR)-
- CBNumber
- CB9838727
- Molecular Formula
- C36H44N4O
- Formula Weight
- 548.76
- MOL File
- 104196-68-1.mol
MANZAMINE A Property
- Boiling point:
- 756.6±60.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- -20°
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- form
- Off white to yellow solid.
- pka
- 13.58±0.40(Predicted)
- color
- Off-White to Pale Yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 21444
- Product name
- Manzamine A
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $129
- Updated
- 2024/03/01
- Product number
- 21444
- Product name
- Manzamine A
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $232
- Updated
- 2024/03/01
- Product number
- M186003
- Product name
- ManzamineA
- Packaging
- 2.5mg
- Price
- $795
- Updated
- 2021/12/16
- Product number
- orb546096
- Product name
- Manzamine A
- Purity
- >98%
- Packaging
- 5mg
- Price
- $1281.8
- Updated
- 2021/12/16
- Product number
- orb546096
- Product name
- Manzamine A
- Purity
- >98%
- Packaging
- 1mg
- Price
- $365.5
- Updated
- 2021/12/16
MANZAMINE A Chemical Properties,Usage,Production
Description
Manzamine A (104196-68-1) inhibits vacuolar ATPases and inhibits autophagy in pancreatic cancer cells1. Suppresses atherosclerosis?in vivo2. Manzamine A displays neuritogenic activity3?and suppresses tau hyperphosphorylation in human neuroblastoma cell lines4.
Uses
Manzamine A is a β-Carboline alkaloid with anti-inflammatory.
Definition
ChEBI: An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26).
storage
+4°C
References
1) Kallifatidis?et al. (2013),?The marine natural product manzamine A targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells; Mar. Drugs,?11?3500 2) Eguchi?et al. (2013),?Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo; Bioorg. Med. Chem.,?21?3831 3) Zhang?et al. (2008),?Neuritogenic activity-guided isolation of a free base form manzamine A from a marine sponge, Acanthostrongylophora aff. Igens (Thiele, 1899); Chem. Pharm. Bull.,?56?866 4) Hamann?et al. (2007),?Glycogen synthase kinase-3 (GSK-3) inhibitory activity and structure-activity relationship (SAR) studies of the manzamine alkaloids. Potential for Alzheimer’s disease; J. Nat. Prod.,?70 139